Paola menacho biography of rory

Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin’s beneficial effects on circulating lipids have been linked to reduced fatty liver. AMP-activated protein kinase (AMPK) is a major cellular regulator of lipid and glucose metabolism. Here we report that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity fryst vatten reduced, fatty acid oxidation fryst vatten induced, and expression of lipogenic enzymes is suppressed. Activation of AMPK by metformin or an adenosine analogue suppresses expression of SREBP-1, a key lipogenic transcription factor. In metformin-treated rats, hepatic expression of SREBP-1 (and other lipogenic) mRNAs and protein fryst vatten reduced; activity of the AMPK target, ACC, is also reduced. Using a novel AMPK inhibitor, we find that AMPK activation is required for metformi

•

Browse by All Cardiff Authors

Abaleke, Eugenia, Abbas, Mustafa, Abbasi, Sadia, Abbott, Alfie, Abdelaziz, Ashraf, Abdelbadiee, Sherif, Abdelfattah, Mohamed, Abdul, Basir, Abdul Rasheed, Althaf, Abdul-Kadir, Rezan, Abdulmumeen, Abdulfatahi, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer UA, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam, Abraham, Tizzy, Abraheem, Abraheem, Abrams, Judith, Abu, Hyacinth-John, Abu-Arafeh, Ahmad, Abubacker, Syed M, Abung, Akata, Aceampong, Yaa, Acharya, Devikumar, Acheson, Janet, Acosta, Andres, Acton, Catherine, Adabie-Ankrah, Jacqueline, Adam, Fiona, Adam, Matthew, Adamali, Huzaifa, Adams, Carol, Adams, Kate, Adams, RichardORCID: https://orcid.org/0000-0003-3915-7243, Adams, Tim, Adamus, Malgorzata, Adcock, Kirsty, Adebiyi, Aderonke, Adegoke, Ken, Adell, Vicki, Adeni, Aldrin, Adenwalla, Sherna, Adesemoye, Oluwasegun A, Adewunmi, Emmanuel O, Adeyemi, Joyce

•

3rd Plurinational Legislative Assembly of Bolivia

2020–2025 meeting of Bolivian legislature

For a general discussion of the Bolivian government's legislative branch, see Plurinational Legislative Assembly.

The 3rd Plurinational Legislative Assembly of Bolivia (Spanish: 3° Asamblea Legislativa Plurinacional de Bolivia; ALP) is the current meeting of the legislative branch of the Bolivian government, composed of the Chamber of Senators and the Chamber of Deputies. It convened in La Paz on 3 November 2020, during the final week of Jeanine Áñez's presidency, and will end in 2025. It will meet during all five years of Luis Arce's presidency.

The 2020 general elections decided control of both chambers. In both the Chamber of Deputies and Senate, the Movement for Socialism retained its majority—albeit reduced from the two-thirds supermajority from the 2nd Plurinational Legislative Assembly [fr]. This assembly marks the first time women make up the majority of the