James daniel sundquist biography of abraham
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Key Points
Question
To what extent is the familial risk of heart failure caused by shared genetic factors?
Findings
In this nationwide study, adoptees showed an increased risk of heart failure (odds ratio, 1.45 [95% CI, 1.04-2.03]) if they had a biological parent with the condition; an affected adoptive parent conferred no such risk. Heritability (h2) of heart failure per Falconer regression was 26%; if cardiomyopathies were excluded, heritability was 34%.
Meaning
A history of heart failure in a biological parent fryst vatten associated with heart failure in adopted children, which suggests that a genetic susceptibility should be considered in clinical practice and should motivate further genetic studies.
This nationwide study of Swedish adoptees and their adoptive and biological parents aimed to determine the heritability of heart failure.
Abstract
Importance
Heart failure (HF) aggregates in families, but the heritability of HF has not been determined. Discerning the genetic a
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Published in final edited form as: Addiction. 2017 May 16;112(8):1386–1394. doi: 10.1111/add.13834
Abstract
Background and aim
Pharmacotherapy can be an important part of the continuum of care for alcohol use disorder (AUD). The Swedish universal healthcare system emphasizes provision of care to marginalized groups. The primary aim was to test associations of neighbourhood deprivation and disadvantaged social status with receipt of AUD pharmacotherapy in this context.
Design
Data from linked population registers were used to follow an open cohort over 7 years.
Setting
Sweden.
Participants
Alcohol-related ICD-10 codes reported for all hospitalizations in the Swedish Hospital Discharge Register and all clinic/office visits in the Outpatient Care Register between 2005–2012 were used to identify 62,549 cases with AUD.
Measurements
The primary outcome was any AUD pharmacotherapy (naltrexone, disulfiram, acamprosate, nalmefe